Weaver Lab
Department of Cell and Regenerative Biology

Publications

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  • Copeland SE, Snow SM, Wan J, Matkowskyj KA, Halberg RB, Weaver BA. 2024. MAD1 upregulation sensitizes to inflammation-mediated tumor formation. PLoS Genetics. doi: 10.1371/journal.pgen.1011437. Link. 
  • Tucker JB, Carlsen CL, Scribano CM, Pattaswamy SM, Burkard ME, Weaver BA. 2024. CENP-E inhibition induces chromosomal instability and synergies with diverse microtubule-targeting agents in breast cancer. Cancer res. doi: 10.1158/0008-5472.CAN-23-3332. Link. 
  • Zhou AS, Tucker JB, Scribano CM, Lynch AR, Carlsen CL, Pop-Vicas ST, Pattaswamy SM, Burkard ME, Weaver BA. 2023. Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles. PLoS Biol. doi: 10.1371/journal.pbio.3002339. Link.
  • Tucker JB, Bonema SC, García-Varela R, Denu RA, Hu Y, McGregor SM, Burkard ME, Weaver BA. 2023. Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer. Cancer Res Commun. doi: 10.1158/2767-9764.CRC-22-0302. Link.
  • Britigan EMC, Wan J, Sam DK, Copeland SE, Lasek AL, Hrycyniak LCF, Wang L, Audhya A, Burkard ME, Roopra A, Weaver BA. 2022. Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability. Front Dev Cell Biol. doi:10.3389/fcell.2022.1018161. Link.
  • Lynch AR, Arp NL, Zhou AS, Weaver BA, Burkard ME. 2022. Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference. Elife. doi: 10.7554/eLife.69799. Link.
  • Cosper PF, Copeland SE, Tucker JB, Weaver BA. 2022. Chromosome Missegregation as a Modulator of Radiation Sensitivity. Semin Radiat Oncol. doi: 10.1016/j.semradonc.2021.09.002. Link.
  • Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O’Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BA. 2021. Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel. Sci Transl Med. doi: 10.1126/scitranslmed.abd4811. Link.
  • Funk LC, Wan J, Ryan SD, Kaur C, Sullivan R, Roopra A, Weaver BA. 2021. p53 Is Not Required For High CIN to Induce Tumor Supression. Mol Cancer Research. doi: 10.1158/1541-7786.MCR-20-0488. Link.
  • Johnson, J.M., Hebert, A.S., Drane, Q.H., Lera, R.F., Wan, J., Weaver, B.A., Coon, J.J., Burkard, M.E. 2020. A Genetic Toggle for Chemical Control of Individual Plk1 Substrates. Cell Chem Biol. 19: 350-362. Link.
  • Singh, A., Denu, R.A., Wolfe, S.K., Sperger, J.M., Schehr, J., Witkowsky, T., Esbona, K., Chappell, R.J., Weaver, B.A., Burkard, M.E., Lang, J.M. 2020. Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer. Mol. Oncol. doi: 10.1002/1878-0261.12687. Link.
  • Jin, N., Lera, R.F., Yan, R.E., Wan, J, Mattison, R.J., Weaver, B.A., Burkard, M.E. 2020. Chromosomal instability is prognostic and upregulates interferon in acute myeloid leukemia. Genes, Chromosomes and Cancer. doi: 10.1002/gcc.22880. Link.
  • Denomy, C., Germain, S., Haave, B., Vizeacoumar, F.S., Freywald, A., Weaver, B.A., Vizeacoumar, F.J. 2019. Banding Together: A Systematic Comparison of The Cancer Genome Atlas and the Mitelman Database. Cancer Res 79: 5181-5190. Link.
  • Wan, J., Block, S., Scribano, C.M., Thiry, R. Esbona, K. Audhya, A. Weaver, B.A. 2019. Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nature Commun 10: 1540-1553. Link.
  • Burkard M.E. and Weaver B.A. 2017. Tuning chromosomal instability to optimize tumor fitness. Cancer Discov 7: 134-136 . Link.
  • Funk L.C., Zasadil L.M., Weaver B.A. 2016. Living in CIN: Mitotic infidelity and its consequences for tumor promotion and suppression. Dev Cell 39: 638-652. Link.
  • Cunningham C.E., Li S., Vizeacoumar F.S., Bhanumathy K.K., Lee J.S., Parameswaran S., Furber L., Abuhussein O., Paul J.M., McDonald M., Templeton S.D., Shukla H., El Zawily A.M., Boyd F., Alli N., Mousseau D.D., Geyer R., Bonham K., Anderson D.H., Yan J., Yu-Lee L.Y., Weaver B.A., Uppalapati M., Ruppin E., Sablina A., Freywald A. Vizeacoumar F.J. 2016. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget 7:61544-61561. Link.
  • Zasadil, L.M., Britigan, E.M.C., Ryan, S.D., Kaur, C., Guckenberger, D.J., Moser, A.R., Weaver, B.A. 2016. High rates of chromosome missegregation suppress tumor progression, but do not inhibit tumor initiation. Mol Biol Cell 27: 1981-9.   Link
  • Denu R.A., Zasadil L.M., Kanugh C., Laffin J., Weaver B.A., Burkard M.E. 2016. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer 16:47. doi: 10.1186/s12885-016-2083-x.   Link
  • Choudhary A., Zachek B., Lera R.F., Zasadil L.M., Lasek A., Denu R.A., Kim H., Kanugh C., Laffin J., Harter J.M., Wisinski K.B., Saha S., Weaver B.A., Burkard M.E. 2016. Identification of selective lead compounds for treatment of high-ploidy breast cancer. Mol Cancer Ther. 15:48-59.   Link
  • Wan, J. and Weaver, B.A. 2015. Mad1 at the Golgi apparatus: a story beyond kinetochores. Cell Cycle 14:1763-4.   Link
  • Hwang B., McCool K., Wan J., Wuerzberger-Davis S.M., Young E.W., Choi E.Y., Cingolani G., Weaver B.A., Miyamoto S. 2015. IPO3 mediated nonclassical nuclear import of NEMO drives DNA damage-dependent NF-?B activation. J Biol Chem 290:17967-84.   Link
  • Wan, J., Zhu, F., Zasadil, L.M., Yu, J., Wang, L., Johnson, A., Berthier, E., Beebe, D.J., Audhya A. and .Weaver, B.A. 2014. A Golgi localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration, Curr Biol 24: 2687–2692   Link
  • Weaver, B.A. 2014. How Taxol/paclitaxel kills cancer cells. Mol Biol Cell 25:2677-81.   Link
  • Britigan, E.M.C., Wan, J., Zasadil, L.M., Ryan, S.D. and Weaver, B.A. 2014. The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B. Mol Biol Cell25:2761-73.   Link
  • Zasadil, L.M., Andersen, K., Ryan, S.D., Yeum, D., Raines, R., Burkard, M.E., and Weaver, B.A. 2014. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Science Translational Medicine 6:229ra43.   Link
  • Silk, A.D.*, Zasadil, L.M.*, Holland, A.J., Vitre, B., Cleveland, D.W. and Weaver, B.A. 2013. The rate of chromosome missegregation determines whether aneuploidy promotes or suppresses tumors, Proc Natl Acad Sci U S A, 110:E4134-41. PMC3816416.  Link
  • Choudhary, A., Lera, R.F., Martowicz, M.L., Oxendinec, K., Laffin, J.J., Weaver, B.A. and Mark E. Burkard. 2013. Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis. Proc Natl Acad Sci U S A, 110:13026-31.   Link
  • Zasadil, L.M., Britigan, E.M.C. and Weaver, B.A. 2013. 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells. Semin Cell Dev Biol, doi:pii: S1084-9521(13)00019-0  Link
  • Harkness, T., Weaver, B.A., Alexander, C. and Ogle, B.M. 2013. Cell Fusion In Tumor Development: Accelerated Genetic Evolution. Crit Rev Oncog 18:19-42  Link
  • Ryan, S.D., Britigan,, E.M.C., Zasadil, L.M., Witte, K., Audhya, A., Roopra, A. and Weaver, B.A. 2012. Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons, Proc Natl Acad Sci U S A, 109: E2205-14.  Link
  • Weaver, B.A. and Cleveland, D.W. 2009. The role of aneuploidy in promoting and suppressing tumors. J Cell Biol185: 935-937  Link
  • Weaver, B.A. and Cleveland, D.W. 2008. The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell. 14:431-3  Link
  • Weaver, B.A., Silk, A.D. and Cleveland, D.W. 2008. Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression. Cell Oncol 30:453  Link
  • Weaver, B.A. and Cleveland, D.W. 2007. Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res 67: 10103-5  Link
  • Weaver, B.A. and Cleveland, D.W. 2007. Comment on “A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint”. Science, 18: 982  Link
  • Weaver, B.A., Silk, A.D., Montagna, C., Verdier-Pinard, P. and Cleveland, D.W. 2007. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell, 11: 25-36  Link
  • Weaver, B.A. and Cleveland, D. W. 2006. Does aneuploidy cause cancer? Curr Opin Cell Biol 18: 658-67  Link
  • Weaver, B.A., Silk, A.D. and Cleveland, D.W. 2006. Nondisjunction, aneuploidy and tetraploidy. Nature 442: 9-10.   Link
  • Kops, G.J.P.L., Weaver, B.A., and Cleveland, D.W. 2005. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5: 773-85  Link
  • Weaver, B.A. and Cleveland, D.W. 2005. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 8: 7-12  Link
  • Kops, G.J.P.L., Kim, Y., Weaver, B.A., Mao, Y., McLeod, I., Yates, J.R., Tagaya, M. and Cleveland, D.W. 2005. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol 169: 49-60.   Link
  • Weaver, B.A., Bonday, Z.Q., Putkey, F.R., Kops, G.J.P.L., Silk, A.D. and Cleveland, D.W. 2003. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol 162: 551-63  Link