In the Weaver lab, we are interested in aneuploidy, an abnormal number of chromosomes, and chromosomal instability (CIN), the rate of continuous chromosomal gains or losses. Aneuploidy and mitotic defects that cause CIN have been recognized as hallmarks of cancer since the early 1900s. Our lab focuses on understanding how chromosome segregation becomes misregulated in cancers, how various cancer treatments affect mitosis, and the consequences of specific chromosome segregation errors on tumor promotion, suppression and therapeutic response.