In the Weaver lab, we are interested in aneuploidy, an abnormal number of chromosomes, and chromosomal instability (CIN), the rate of continuous chromosomal gains or losses. Aneuploidy and mitotic defects that cause CIN have been recognized as hallmarks of cancer since the early 1900s. Our lab focuses on understanding how chromosome segregation becomes misregulated in cancers, how various cancer treatments affect mitosis, and the consequences of specific chromosome segregation errors on tumor promotion, suppression and therapeutic response.
Consequences of Aneuploidy
Clinically relevant doses of paclitaxel induce chromosome missegregation, not mitotic arrest.
New mechanism discovered for decades-old cancer drug.
From bugs to plants to animals, for all living things to grow they must create more cells. To do so, each existing cell, whether in an embryo or an adult, receives cues to copy its chromosomes — large pieces of DNA that contain each cell’s entire genetic code. In a carefully and elegantly controlled process, each cell then divides into two.
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