Clinically relevant doses of paclitaxel induce chromosome missegregation, not mitotic arrest.
New mechanism discovered for decades-old cancer drug.
From bugs to plants to animals, for all living things to grow they must create more cells. To do so, each existing cell, whether in an embryo or an adult, receives cues to copy its chromosomes — large pieces of DNA that contain each cell’s entire genetic code. In a carefully and elegantly controlled process, each cell then divides into two.